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The amino acid oxidase interleukin-4-induced-1 (IL4i1), originally discovered as a gene induced in B cells in response to IL-4, generates the metabolite indole-3-pyruvate, which suppresses ferroptosis both through a radical scavenging mechanism and by orchestrating a gene expression profile that attenuates ferroptosis (Zeitler et al., 2021) (Figure 2)

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Pregnant or breastfeeding individuals should consult their healthcare provider before using this injection