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For any synthetic AT developed, it is important to know which biomolecule the agent is designed to protect, by which mechanism (scavenging RS, preventing RS formation, increasing endogenous defense mechanisms, and/or supporting oxidative damage repair), whether it can generate RS, and if there are any adverse effects associated with RS suppression

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62 Regarding endoscopic therapy of PSC, and particularly the dilatation of high‐grade strictures in symptomatic patients using bougies or balloon catheters, it is salutary to accept that these skillful manipulations, which have gratifying short‐term success, 63 , 64 have yet to be sanctioned by randomized controlled trials but, nonetheless, are recommended 59 , 65 in patients with, what are now termed, clinically relevant 66 strictures