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Notably, administration of Fer-1 or overexpression of SIRT7 effectively alleviated Ang II-induced epithelial-mesenchymal transition (EMT) and renal ferroptosis in hypertensive mice by suppressing the KIM-1/NOX4 signaling pathway and activating the KLF15/NRF2 and xCT/GPX4 signaling pathways, respectively [263]

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