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Abstract Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low clinical penetrance, caused by mutations in the hydroxymethylbilane synthase ( HMBS ) gene, which encodes the third enzyme in the haem biosynthesis pathway

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Despite the promising preclinical data, further large-scale clinical trials are warranted to establish the efficacy and safety of these agents in psoriasis patients receiving systemic therapies