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The collagen fiber type transitions gradually from the outer to the inner layers—the outer layer is primarily composed of tension-resistant type I collagen, while moving inward, it gradually mixes with type II collagen extending to the edge of the nucleus pulposus, forming a tough ring structure that provides mechanical support to the disc by restricting NP displacement and resisting compressive loads

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10.1002/(SICI)1097-0045(19970901)32:4%3c229::AID-PROS1%3e3.0.CO;2-E [DOI] [PubMed] [Google Scholar] Bakhoum SF, Ngo B, Laughney AM et al (2018) Chromosomal instability drives metastasis through a cytosolic DNA response