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Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla

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Nies and Keppler (2007) present evidence that ABCC2 is the major transporter for the elimination of glutathione S -conjugate, glucuronic acid conjugate and sulfate conjugate of various toxins and carcinogens from hepatocytes into the bile, from kidney proximal tubule cells into urine, and from intestinal epithelial cells into the intestinal lumen