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As a result, the ER redox state following proteasome inhibition was initially oxidized up to 2 h, and then, became reduced under control of a transcription factor ATF4 induced by accumulation of the ER misfolded proteins (Figs

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Similarly, neuronal hypersynchrony is observed in models of AD 102,103 and can manifest as clinical or subclinical epilepsy, which can occur during the early stages of AD 104,105,106,107,108,109,110