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Interestingly, activated NF-κB can bind directly on the Nrf2 promoter, regulating the transcription of the NRF2 gene and, in turn, stimulating antioxidant response [18] (Figure 1)

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In a dominant-lethal assay with mice, relatively high intravenous doses of ethylene oxide (up to 100 mg/kg body weight) did not cause any treatment-related effects (Appelgren et al., 1977)