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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and blood–brain barrier penetration—using DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entry—loaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

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