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Histamine can trigger: Facial flushing Burning sensations Heat intolerance Redness Inflammatory skin reactions The Role of DAO DAO (diamine oxidase) is the primary enzyme responsible for breaking down dietary histamine

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Thus, it may be that maintained increased intra-abdominal pressure causes widespread dysfunction, which would be similar to the severe syndromes observed in rats with the occlusion of peripheral vessels (Vukojevic et al., 2018