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The Need for Broader Targeted Therapy Options While approximately half of lung adenocarcinomas harbor actionable oncogenic mutations, with targeted therapies available for EGFR (exon 19 deletions, exon 20 insertion, and L858R point mutations), KRAS-G12C, BRAF, MET, HER2, ALK, ROS1, RET, and NTRK alterations (80), the remaining half and nearly all squamous cell lung cancers lack identifiable oncogenic driver alterations, leaving them mostly without precision-targeted treatment options

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[DOI] [PubMed] [Google Scholar] Bray H.G., Franklin T.J., James S.P