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As for vitamin D metabolism, several potential biomarkers related to the VDR , such as the rs2238135 (57) polymorphism and the presence of more than 20 adenine repeats in the 3’ untranslated region of the gene, were associated with a higher risk of PCa (74)

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N 2 O abuse may induce vitamin B12 deficiency, leading to hyperpigmentation of the skin, hair changes, megaloblastic anemia, pancytopenia, subacute combined degeneration, depression, psychosis, and a possible increased risk of myocardial infarction and stroke