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Studies showed that probiotic supplementation can both increase bone density and protect against primary (estrogen-deficiency) and secondary osteoporosis ( - Hypocholestaemic action ( - Anti-carcinogenic, antimutagenic and anti-allergic activities ( - Production of H 2 O 2 by probiotics promotes epithelial restitution ( - Production of antimicrobial agents, organic acids and bacteriocins ( - Their action on the intestinal immune system ( Figure 1 Specifically, some probiotics induce activation of CD4 + and CD8 + T lymphocytes and secretion of IgA by lamina propria plasma cells to neutralize pathogens, while other probiotics suppress the Th1 inflammatory response and the production of inflammatory cytokines IL-12, TNF-a, and stimulate Treg lymphocytes ( Undoubtedly antibiotics play a crucial role in the treatment of infections, however their uncontrollable use has led to serious ecological consequences but also for human health, as for example the increase of multi-resistant strains and the alteration of human floras and specifically of the intestinal microbiota and its functions ( According to WHO, probiotics are “living microorganisms, which, when consumed in adequate amounts, have a health benefit for the host.” Historically, Metchnikoff was the first scientist to propose the use of probiotics
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