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But CNI inhibitor-induced excess secretion of ULVWF strings appears to overwhelm the capacity of ADAMTS-13 activity, thereby leading to platelet thrombi and TTP

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These extracts usually contain several enzymes (including proteases, phosphatases, nucleases, oxidoreductases, and glycosidases), but the most characteristics among them are some cysteine endopeptidases that specifically hydrolytically cleave non-terminal peptide bonds ( Table 1