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Snapshot Proponents : May help with obesity and diabetes by replacing sugar Zero calories and rich in nutrients May have anticancer effects May protect the liver May combat infections and fatigue Skeptics : Can be costly Potential benefits lack clinical evidence Long-term safety is unknown Components Monk fruit has: Zero calories [2, 3] Vitamin C , which decreases blood histamine levels and maintains collagen [4, 5] Kaempferol , a flavonoid with potent antimicrobial and antioxidant effects [6, 7] Triterpene glycosides , compounds that suppress reduce the growth of tumor cells [8, 9] Mogrosides I-V [8]: Cucurbitacins , compounds that have anti-inflammatory effects by inhibiting TNF-alpha and COX-2 [13, 14] Polysaccharide fibers , which lower cholesterol levels [15, 16] Mechanism of Action Monk fruit extract contains mogrosides , antioxidants that decrease blood vessel leakiness (permeability), inhibit histamine release from mast cells, and prevent inflammatory damage