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Specifically, MBOAT2 selectively transfers monounsaturated fatty acids (MUFA) to lysophosphatidylethanolamine (lyso-PE), thereby increasing cellular PE–MUFA and correspondingly reducing PE–PUFA (polyunsaturated fatty acids) (141)

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The positive feedback between Nrf2 and active PI3K–Akt signaling, which induces the malignant evolution of cancers, presents another area of interest for therapeutic development