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113 Moreover, globular adiponectin was also found to prevent APAP-induced hepatocyte death, which was achieved partly through the inhibition of ERS and inflammasome activation by inducing autophagy

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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans