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These clusters are trafficked by ISC-targeting factors, such as proteins from the BolA family and iron-sulfur cluster scaffold homolog 1 (NFU1) to apo-target proteins such as the mitochondrial aconitase (ACO2)

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Sugar-sensing allows them to adjust cellular metabolism to best utilize the available resources and respond appropriately during periods of nutrient stress (Thevelein and de Winde, 1999)