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Unfortunately, there remain certain significant limitations to such therapy, namely the short half-life and side effects of BDNF as well as, according to some authors, the need to cross the blood–brain barrier (BBB) [111]

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doi: 10.1016/j.phrs.2024.107312 [DOI] [PMC free article] [PubMed] [Google Scholar] 158.Long B, Pelletier J, Koyfman A, Bridwell RE

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