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4.5 Inhibitors of dipeptidyl peptidase-4 (DPP-4) Dipeptidyl peptidase-4 (DPP-4) inhibitors exert their effects by blocking DPP-4 enzymatic activity, thereby preventing the degradation of endogenous incretin hormones—primarily glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)