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In HEK293 cells, the ΔNΔC α 1D -AR mutant, characterized by a C-tail truncation (in addition to an N-terminal truncation), did not alter the noradrenaline-induced calcium signaling, whereas the ΔN-MutIL3 mutant, characterized by a mutated intracellular loop (in addition to an N-terminal truncation) demonstrated a decreased ability to increase intracellular calcium after stimulation with noradrenaline

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Kimji evaluates the consistency between editorial claims and the published clinical evidence, the appropriateness of contraindication language, and the alignment between protocol recommendations and standard-of-care dermatology practice

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