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In particular, metabolism of HNE or its glutathione conjugate GS-HNE can result in products, such as 1, 4-dihydroxynonene (DHN) and glutathionyl-1,4-dihydroxynonane (GS-DHN), which are still toxic and promote activation of phospholipase C (PLC)-NF-κB cascades perpetuating inflammation (Ramana et al., 2 (Ramana and Srivastava, Interestingly, AKR1B1 displays PGF2α synthetizing activity through which it can regulate PGE 2 production (Bresson et al., 1 and PGE 2 and their cyclopentenone products, PGA 1 and PGA 2 , which results in inhibition of the enzyme (Díez-Dacal et al., AKR1B1 in allergic reactions Early reports linking AKR1B1 to hypersensitivity provided fragmented pieces of evidence
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