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The functional categorization of Afu-depleted metabolites revealed a shift from glucose metabolism toward alternative sugar sources such as fructose, galactose and mannose

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APE1 is a 37 kDa ubiquitous multifunctional protein involved in the regulation of multiple transcription factors, including NF-κB, STAT3, AP-1, hypoxia-inducible factor-1 (HIF-1), and tumor protein 53 (p53