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During the progression of CRC, the Wnt/β-catenin pathway is activated, and usually accompanied by increased tumor cell proliferation and invasion ( FIGURE 5 4 Therapeutic applications of pharmacological agents targeting the Wnt/β-catenin signaling pathway in CRC treatment The Wnt/β-catenin signaling pathway plays a pivotal role in the pathogenesis and progression of CRC through its regulation of β-catenin stability in the cytoplasm

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4) How does a change in IGF-I signaling contribute to disease states, like osteoporosis, osteoarthritis, bone cancer metastasis and fracture healing

ALC has been shown to reduce both physical and mental fatigue associated with aging