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In astrocytes, Cu toxicity is associated with oxidative stress, as treatment with antioxidants mitigates Cu-induced cell death, demonstrating that oxidative stress mediates Cu-induced astrocyte cytotoxicity (Gale et al., 2023)

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The importance of ATM in the cellular response to oxidative stress can be seen by investigating its role in the autosomal recessive disorder ataxia telangiectasia (A-T), after which ATM is named 55