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Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[3] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[4] However, it is recommended to consult a healthcare professional before using any new product on the skin or scalp

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This suggests that in this airway inflammation model, L-NAME exhibits a different activity on NOS isoforms, presumably blocking eNOS but not iNOS (Vasconcelos et al., 2020)