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Changes or mutations in the genetic coding of GST isoenzymes, such as glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase Theta 1 (GSTT1), result in decreased GSTM1 and GSTT1 enzymatic activity

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This may be particularly useful for investigating heterogeneity in small sections of tissue, a common occurrence with human liver biopsies, where both transcriptomics and spatial positioning can be derived from a single tissue section without material loss