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The oral-contraceptive interaction is a separate study (GPGR), reported in the FDA Mounjaro NDA 215866 summary review: a single 5 mg tirzepatide dose with a combination oral contraceptive (0.035 mg ethinyl estradiol / 0.25 mg norgestimate) reduced the Cmax of norelgestromin and ethinyl estradiol by 55% to 59% — a range spanning both analytes, not a separate figure for each — with AUC lowered 28.8% (norelgestromin) and 27% (ethinyl estradiol), and tmax delayed 2.5 to 4.5 hours

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One study posited that a GHK-Cu possibly reduces visible bioindicators, improving skin laxity and clarity