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Initially, these macrophages appear to have a pro-inflammatory M1 phenotype which are best known for their ability to engulf tissue debris and bacteria, but later M2 macrophages (242), which in other systems produce active TGFβ to quell the inflammatory response are detected (243) although their role in inducing the fibrotic response of LECs is currently unclear as cellular ablation of circulating macrophages did not appear to ameliorate capsular bag fibrosis following lens injury in rats (244)

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Variations in the level of free sphinganine and the relationship between sphinganine/ sphingosine were observed