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Moving a sample from freezer temperatures (around minus 20 C) to room temperature (around 25 C) therefore represents a large cumulative increase in thermal energy across that span, corresponding to substantially faster degradation

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METALLURGY C07—ORGANIC CHEMISTRY C07D—HETEROCYCLIC COMPOUNDS C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms C—CHEMISTRY