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These mistakes account for most reconstitution failures and the disappointing results that follow

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Such latent proximity inducers are prime candidates for degraders, as evident from a number of studies on CRBN as well as other E3 ligases correlating cellular degradation with biochemical binding properties, reporting that an approximately two- to threefold increase in target binding to CRBN–MGDs suffices to convert CRBN–MGD-bound proteins into robustly degraded ones 24,26