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Une exposition chronique aux sources de radicaux libres — pollution atmosphérique, tabac, alcool, stress, alimentation pro-oxydante, médicaments — épuise les réserves plus vite qu'elles ne se reconstituent

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In mice subjected to the CUMS paradigm, RES treatment reversed anxiety-like behavior and improved mitochondrial dysfunction via the SIRT1/PGC1/SIRT3 pathway [175]