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Expected milestones during therapy: Baseline assessment and initial labs Early symptom change (2–6 weeks) Objective lab improvement (6–12 weeks) Dose optimization and protocol refinement (3 months) Long-term maintenance or tapering plans (6–12 months) Expectations While most patients experience progressive symptom relief, some begin to notice changes within 2 to 6 weeks, with measurable reduction in inflammation present by 8 to 12 weeks