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PAPS builds compounds you cannot absorb intact: Chondroitin sulfate — connective tissue, joints, skin Dermatan sulfate — clotting, wound repair, vascular health Keratan sulfate — hair, skin, nails, cornea Heparan sulfate — growth factors and cytokine signalling Cerebroside sulfate — the water permeability barrier of skin Tyrosine-O-sulfate — clotting factors and neurotransmitter clearance Taurolithocholate sulfate — a bile salt involved in fat digestion Oestrone-3-sulfate — hormone storage and transport It also drives the sulfation of mucin, the protective gel layer over your gut lining
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Besides the amyloidogenic proteins, several other proteins have also been shown to be able to punch holes in mitochondria through interaction with cardiolipin, including members of the Bcl-2 family, cobra venom cardiotoxins and bacterial toxins (Vassallo, 2025)
