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On the other hand, NRF2’s novel function as an oncogene was demonstrated by the identification of its hyperactivation in a significant number of cancers, which gave tumor cells an advantage and led to the encouragement of growth and therapeutic resistance

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[DOI] [PMC free article] [PubMed] [Google Scholar] Frederick DW, Davis JG, Davila A, Jr, Agarwal B, Michan S, Puchowicz MA, Nakamaru-Ogiso E, Baur JA