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Consequently, despite the clear message of landmark trials such as the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study regarding the need for excellent glycemic control, diabetes remains the leading cause of blindness, renal failure, and amputations

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When inflammation becomes chronic, overproduction of reactive oxygen species (ROS) such as superoxide (O 2 − ) and hydrogen peroxide (H 2 O 2 ) can be observed [3]