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"MOTS-c is one of the few mitochondria-derived signals with confirmed activity in human tissue samples, giving it a translational relevance that most metabolic peptides cannot yet claim." Questions 5-Amino-1MQ Is Built to Answer 5-Amino-1MQ is a more specialized instrument

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The predicted binding mode of 1j indicates the C5′-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue