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Bioavailability has also been directly assessed by measuring polyphenol concentrations in plasma and urine after ingestion of purified compounds or polyphenol-rich foods (114)

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Maternal betaine intake (rats and pigs) can programmatically alter liver metabolism, cell proliferation, and the developmental trajectory of offspring—and even the F2 generation—by affecting the DNA methylation pattern of the insulin-like growth factor (IGF) gene family (IGF-1/2) in the liver of the offspring and regulating the expression of glucocorticoid receptor signaling and lipolysis genes (adipose triglyceride lipase and hormone-sensitive lipase) (25, 140–145)