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CCK-8 assay (D) , EdU assay (E) and cell cycle assay (F) were performed after DPCs treated with anti-miR-NC, anti-miR-221 + PD98059 and anti-miR-221, as well as DSCs treated with anti-miR-NC, anti-miR-221 + LY294002 and anti-miR-221

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The change in HbA1c ranged from −1.87% to −2.59% for various doses of tirzepatide compared to placebo, −1.86% for weekly 1 mg semaglutide in the SURPASS-2 trial, −1.34% for degludec insulin in the SURPASS-3 trial, and −1.44% for glargine insulin in the SURPASS-4 trial [94,95,96] (Figure 7)