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on the other hand, when monocytes reach the necrotic area, they can be transformed into monocyte-derived macrophages, which leads to a rapid increase in the number of hepatic macrophages

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Furthermore, the protein levels of progerin, Lamin A/C, and p53 in primary hepatocytes on Day 6 and Day 28 were also predominantly downregulated by IGF-1 overexpression (Fig