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Choice B: Fibrinogen (Factor I) deficiency, such as afibrinogenemia, is a rare bleeding disorder characterized by the absence or severe reduction of circulating fibrinogen

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The hypotheses are oriented according to a multifactorial logic, immunoreumatological in nature with neurological, psychiatric, muscular and metabolic symptoms, although (being a diagnosis by exclusion) it tends to include known phenomena (such as psychiatric symptoms) in a spectrum of heterogeneous symptoms, thus risking diagnostic error, even to accommodate the patient’s needs and wants