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Similar phylogenetic distributions of TrxR-“type” and transsulfuration-“direction” Intriguingly, metazoans acquired a novel TrxR enzyme via gene duplication and specialization of Gsr [53, 54] apparently coincident with loss of their Cys → Hcy transsulfuration capacity (Fig

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A number of these studies have been included below to demonstrate the evidence base for the medicinal actions discussed in this monograph

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