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For atherosclerosis studies, eight-week-old male Apoe −/− mice were fed ad libitum either an amino acid (AA)-defined Western diet (Envigo-Teklad, 42% fat, 0.2% cholesterol) with glycine (WD AA + Gly, TD.170525) or without glycine (WD AA -Gly, TD.170526), as we previously described [8], a standard Western diet (WD, Envigo-Teklad TD.88137, 42% fat, 0.2% cholesterol) or a low-fat standard diet (SD, LabDiet 5L0D, 13% fat)