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Mechanisms of apoptotic cell death induced by platinum-containing drugs Cisplatin-induced DNA damage is recognized by special cellular machinery, which includes MRE11-RAD50-NBS1 (MRN) complex [17, 18], hMSH2 of the mismatch repair (MMR) complex, the nonhistone chromosomal high-mobility groups 1 and 2 proteins (HMG1 and HMG 2) and the transcriptional factor “TATA-binding protein” (TBP) [19]

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Ammonia and autophagy: An emerging relationship with implications for disorders with hyperammonemia