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In 2017, Japanese researchers successfully transplanted a sheet of patient-specific hiPSC-derived retinal pigment epithelial cells into a patient with age-related macular degeneration, which remained intact at one year post-operatively but without significant improvement in visual acuity ( Extending from this idea is that of the organoid, which is made of patient-derived stem cells grown in carefully selected media that determines differentiation then put onto an extracellular matrix to function as an organ ( in vitro ( Recent studies have expanded the utility of organoids to model complex genetic disorders and to enhance their function through vascularization