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Notably, in glomerular diseases such as DKD [40], IgA nephropathy [41], membranous nephropathy (MN), and focal segmental glomerulosclerosis (FSGS) [42], epithelial senescence is frequently observed and correlates more closely with patient outcomes than glomerular lesions [43]

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Bacterial translocation, even if physiological within certain limits, can be the original factor triggering liver injury or an additional cause in patients with other pre-existing viral or metabolic diseases and increased intestinal permeability, in particular those with liver cirrhosis