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It has been found that various metabolic pathways and biomolecules are implicated in the progression of COPD, including amino acid metabolism dysfunction, energy metabolism dysfunction, lipid metabolism dysfunction, and oxidative and antioxidant imbalance, via the stimulation of the NF-κB signaling pathway and the emission of inflammatory cytokines, causing protein malnutrition and oxidative stress, which in turn add to the development and worsening of COPD (Corradi et al