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ROS have been implicated in this destructive process • EUK-134, a newly reported salen-manganese complex having greater catalase and cytoprotective activities and equivalent SOD activity compared with the prototype EUK-8 Small molecules mimicing antioxidantenzymes • Mn(II) complex M40403 (a synzyme) • possesses SOD activity approaching that of the native Mn-SOD enzyme • possessing outstanding chemical and biological stability • Removes superoxide without interfering with other relevant biological oxidants, such as nitric oxide, peroxynitrite, or hydrogen peroxide