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Disulfide linkers exploit the reducing environment inside cells to release drugs in lysosomes following internalization and antibody degradation

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The latter can be caused by complete or partial deficiency of the enzyme methyl­malonyl‑CoA mutase, which requires vitamin B12 as a co-factor (5‑deoxy-adenosyl-cobalamin (Ado‑Cbl)) (Figure 22b.7)

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