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In addition, they induce the release of latent TGF-β, and chronic inflammation perpetuates its activation, creating a vicious cycle that leads to abnormal healing and the formation of hypertrophic scars [111,112,113]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Tosi G.M., Giustarini D., Franci L., Minetti A., Imperatore F., Caldi E., Fiorenzani P., Aloisi A.M., Sparatore A., Rossi R., et al